Article

Spatial Distribution of Missense Variants within Complement Proteins Associates with Age Related Macular Degeneration

2023-08-31

Abstract excerpt

<h4>Purpose</h4> Genetic variants in complement genes are associated with age-related macular degeneration (AMD). However, many rare variants have been identified in these genes, but have an unknown significance, and their impact on protein function and structure is still unknown. We set out to address this issue by evaluating the spatial placement and impact on protein structureof these variants by developing an...

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Literature Corpus work: fc02ed4e-edbb-5718-b566-77786752bb12
DOI: 10.1101/2023.08.28.23294686

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