Article

Germline mutations of TP53 gene can be a key factor in prostate cancer genesis

2024-03-22

Abstract excerpt

<h4>Background: </h4> The TP53 gene is one of the most important agent of the DNA repair pathway. Alterations of this gene have been found in more than 50% of human primary tumors including prostate cancer. The germline TP53 mutation is responsible for Li-Fraumeni syndrome, which is associated with a predisposition to several cancers. Objective The aim of this study is to investigate whether germline alterations...

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Literature Corpus work: fbfad2e0-1ec8-5528-9b5a-c62f08cf9dae
DOI: 10.21203/rs.3.rs-4125940/v1

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