Article

The QNOAEL vs. BMD for Point of Departure

2018-05-24

Abstract excerpt

Quantile bootstrap (QB) methods can be applied to the problem of estimating the No Observed Adverse Effect Level (NOAEL) of a New Molecular Entity (NME) to anticipate a safe starting dose for beginning clinical trials. An estimate of the NOAEL from the extended QB method (called the QNOAEL) can be calculated using multiple disparate studies in the literature and/or from laboratory experiments. The QNOAEL is simila...

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Literature Corpus work: fbd7db10-eb49-5bc4-9118-bc64030d42e6
DOI: 10.1101/329763

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