Article

Recommendations to address uncertainties in environmental risk assessment using toxicokinetics-toxicodynamics models

2018-06-27

Abstract excerpt

<h4> A BSTRACT </h4> Providing reliable environmental quality standards (EQSs) is a challenging issue in environmental risk assessment (ERA). These EQSs are derived from toxicity endpoints estimated from dose-response models to identify and characterize the environmental hazard of chemical compounds such as those released by human activities. These toxicity endpoints include the classical x % effect/lethal con...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d0fa38a-9281-5c42-8d83-d7febc72ba22
DOI: 10.1101/356469

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recommendations to address uncertainties in environmental risk assessment using toxicokinetics-toxicodynamics modelsDOI 10.1101/356469Read

Enabling Transparent Toxicokinetic Modeling for Public Health Risk AssessmentSemantic proximity Read

IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs).Semantic proximity Read

Mixture Toxicity: Evidence from Experimental Studies on Concurrent Chemical ExposuresSemantic proximity Read

Mixture Toxicity: Evidence from Experimental Studies on Concurrent Chemical ExposuresSemantic proximity Read

Gene expression, dose-response, and phenotypic anchoring: applications for toxicogenomics in risk assessment.Semantic proximity Read

A new approach for risk assessment of pulmonary toxicants: a preliminary study using didecyldimethylammonium chlorideSemantic proximity Read

High-throughput PBTK models for in vitro to in vivo extrapolationSemantic proximity Read

Comparing metal toxicity among Daphnia magna clones: an approach using concentration-time-response surfaces.Semantic proximity Read

ECORISK2050: An Innovative Training Network for predicting the effects of global change on the emission, fate, effects, and risks of chemicals in aquatic ecosystemsSemantic proximity Read

The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAMs) in Pharmaceuticals and Environmental Chemical Risk AssessmentSemantic proximity Read

Per- and polyfluoroalkyl substances (PFAS) Regulatory Frameworks, Sources, Occurrence, Fate, and Exposure: Trend, Concern, and ImplicationSemantic proximity Read

The QNOAEL vs. BMD for Point of DepartureSemantic proximity Read