Article
The role of ferroptosis in acute kidney injury: the preemptive mode of cell death and the bridging effect
29 Aug 2025
Abstract excerpt
Ferroptosis represents a distinctive mechanism of cell death, differing from necroptosis, necrosis, and apoptosis. It is triggered by the accumulation of lipid peroxides, driven by iron-catalyzed reactions. This oxidative damage is essential for triggering the ferroptotic pathway. Compared with apoptosis and necroptosis, ferroptosis is activated earlier in acute kidney injury (AKI), serving as a preemptive...
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