Article

LSD1 regulates autophagy and apoptosis by acting through the PI3K/Akt/mTOR signaling pathway in spinal cord injury

2023-09-08

Abstract excerpt

The epigenetic enzyme lysine-specific demethylase 1 (LSD1) can negatively regulate autophagy in nerve injury diseases. Inhibition of LSD1 can enhance autophagy, attenuate apoptosis, and provide effective neuroprotection after spinal cord injury (SCI). However, existing studies have not fully interrogated the specific mechanisms through which LSD1 promotes autophagy and inhibits apoptosis. We tested if LSD1 induces...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fbb68810-48e3-5489-8d70-e2f21fee2a91
DOI: 10.21203/rs.3.rs-3301436/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LSD1 regulates autophagy and apoptosis by acting through the PI3K/Akt/mTOR signaling pathway in spinal cord injuryDOI 10.21203/rs.3.rs-3301436/v1Read

miR‐181d‐5p promotes neurite outgrowth in PC12 Cells via PI3K/Akt pathwaySemantic proximity Read

KDM1A/LSD1 as a promising target in various diseases treatment by regulating autophagy networkSemantic proximity Read

Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicingSemantic proximity Read

HMGA1 Induction of miR-103/107 Forms a Negative Feedback Loop to Regulate Autophagy in MPTP Model of Parkinson’s DiseaseSemantic proximity Read

Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injurySemantic proximity Read

LIR-dependent LMX1A/LMX1B autophagy crosstalk shapes human midbrain dopaminergic neuronal resilienceSemantic proximity Read

SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy.Semantic proximity Read

SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cellsSemantic proximity Read

NBS1, the Nijmegen breakage syndrome gene product, regulates neuronal proliferation and differentiation.Semantic proximity Read

Neuroprotective Effects of Oxymatrine via Triggering Autophagy and Inhibiting Apoptosis Following Spinal Cord Injury in RatsSemantic proximity Read

Down-regulated miR-10a protects against spinal cord injury by up-regulating SIRT1Semantic proximity Read

The protective effect of microRNA-21 in neurons after spinal cord injurySemantic proximity Read