Article

HIV-2/SIV Vpx antagonises NF- <i>κ</i> B activation by targeting p65

2021-06-27

Abstract excerpt

The NF- κ B family of transcription factors and associated signalling pathways are abundant and ubiquitous in human immune responses. Activation of NF- κ B transcription factors by viral pathogen-associated molecular patterns, such as viral RNA and DNA, is fundamental to anti-viral innate immune defences and pro-inflammatory cytokine production that steers adaptive immune responses. Diverse non-viral stimuli, su...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fba15954-b3a1-523d-b0b7-c6d1986f643f
DOI: 10.1101/2021.06.26.450035

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HIV-2/SIV Vpx antagonises NF- <i>κ</i> B activation by targeting p65DOI 10.1101/2021.06.26.450035Read

Transcriptomic analysis reveals key pathways influenced by HIV-2 VpxSemantic proximity Read

HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrestSemantic proximity Read

HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrestSemantic proximity Read

Differential dysregulation of β-TrCP1 and -2 by HIV-1 Vpu leads to inhibition of canonical and non-canonical NF-κB pathways in infected cellsSemantic proximity Read

Dynamic roles for NF‐κB in HTLV‐I and HIV‐1 retroviral pathogenesisSemantic proximity Read

Illuminating the Role of Vpr in HIV Infection of Myeloid CellsSemantic proximity Read

A Mass Spectrometry-Based Profiling of Interactomes of Viral DDB1- and Cullin Ubiquitin Ligase-Binding Proteins Reveals NF-κB Inhibitory Activity of the HIV-2-Encoded VpxSemantic proximity Read

Primate Lentiviruses Modulate NF-κB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene ExpressionSemantic proximity Read

HIV-2/SIV Vpx targets a novel functional domain of STING to selectively inhibit cGAS–STING-mediated NF-κB signallingSemantic proximity Read

Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivoSemantic proximity Read

Mechanisms of Immune Evasion in HIV-1: The Role of Virus-Host Protein InteractionsSemantic proximity Read

The Human Immunodeficiency Virus Type 2 Vpx Protein Usurps the CUL4A-DDB1 DCAF1 Ubiquitin Ligase To Overcome a Postentry Block in Macrophage InfectionSemantic proximity Read