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Iterative Extracellular Vesicle Protein Co-Expression Biomarker Refinement for Preoperative Classification of Histopathological Growth Patterns in Colorectal Liver Metastasis Patients

2026-02-04

Abstract excerpt

Preoperative triage of colorectal liver metastases (CRCLM) by histopathological growth pattern (HGP)—angiogenesis-dependent desmoplastic (dHGP) and vessel co-opting replacement (rHGP)—could guide anti-angiogenic therapy, yet HGP scoring requires resected tissue. We present an extracellular vesicle (EV) inner and outer protein (EVPio) co-expression assay and iterative biomarker refinement for plasma-based HGP class...

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Literature Corpus work
fb93c7fd-bfcf-5a9d-b16d-f713ceb5be39
DOI
10.64898/2026.02.02.702621
Open publication

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Iterative Extracellular Vesicle Protein Co-Expression Biomarker Refinement for Preoperative Classification of Histopathological Growth Patterns in Colorectal Liver Metastasis PatientsDOI 10.64898/2026.02.02.702621
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