Article

Decoding the Circulating Proteome: Matrix and Immune Context Markers Shape Early Multi-Cancer Detection

2025-11-12

Abstract excerpt

<h4>Background</h4> Blood-based proteomics offers a complementary path to multi-cancer early detection (MCED) by capturing the tumor secretome and host response. We analyze recent (2020–2025) evidence and add pathway/hallmark context, cross-platform validation, and proteome-scale protein–protein interaction (PPI) inference to guide translational panel design. <h4>Methods</h4> We reviewed extensive prospective an...

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Literature Corpus work: 64ea17b7-dfa0-5389-9673-0756dc2b6b7e
DOI: 10.1101/2025.11.10.687473

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