Article

Computationally hybridized pathogenic mammarenavirus receptor binding domains reveal cryptic variants that elicit cross-neutralizing immune responses

2026-06-10

Abstract excerpt

The pathogenic mammarenaviruses, Machupo (MACV) and Junin (JUNV), are under evolutionary pressure to leverage human transferrin receptor 1 (hTfR1) for cellular entry while evading host immune responses during zoonosis. We now structurally and functionally investigate cryptic, computationally hybridized JUNV-MACV GP1 sequence variants. We then evaluate the ability of those variants to facilitate internalization of...

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Literature Corpus work: fb7eba71-8379-58ec-a9af-c11b6b7c6205
DOI: 10.64898/2026.06.07.730625

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