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Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization

19 Jun 2017

Abstract excerpt

Transmission of hemorrhagic fever New World arenaviruses from their rodent reservoirs to human populations poses substantial public health and economic dangers. These zoonotic events are enabled by the specific interaction between the New World arenaviral attachment glycoprotein, GP1, and cell surface human transferrin receptor (hTfR1). Here, we present the structural basis for how a mouse-derived neutralizing...

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PMID: 28630325
DOI: 10.1073/pnas.1702127114

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