Article

SARS-CoV-2 NSP12 associates with the TRiC complex and the P323L substitution is a host adaption

2023-03-20

Abstract excerpt

<h4>Summary</h4> SARS-CoV-2 emerged into the human population in late 2019 and human to human transmission has dominated the evolutionary landscape and driven the selection of different lineages. The first major change that resulted in increased transmission was the D614G substitution in the spike protein. This was accompanied by the P323L substitution in the viral RNA dependent RNA polymerase (RdRp) (NSP12). Tog...

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Literature Corpus work: fb48b907-d1d6-546b-94d1-042234e34312
DOI: 10.1101/2023.03.18.533280

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