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Targeting Gene C9orf72 Pathogenesis for Amyotrophic Lateral Sclerosis

30 Apr 2025

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal adult neurodegenerative disorder. Since no cure has been found, finding effective therapeutic targets for ALS remains a major challenge. Gene C9orf72 mutations with the formation of hexanucleotide repeat (GGGGCC) expansion (HRE) have been considered the most common genetic pathogenesis of ALS. The literature review indicates that the C9orf72 HRE causes both the...

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PMID: 40362512
DOI: 10.3390/ijms26094276

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