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Identifying the protective effects of miR ‐874‐3p/ ATF3 axis in intervertebral disc degeneration by single‐cell RNA sequencing and validation

1 Jun 2024

Abstract excerpt

Intervertebral disc degeneration (IVDD) severely affects the work and the quality of life of people. We previously demonstrated that silencing activation transcription factor 3 (ATF3) blocked the IVDD pathological process by regulating nucleus pulposus cell (NPC) ferroptosis, apoptosis, inflammation, and extracellular matrix (ECM) metabolism. Nevertheless, whether miR-874-3p mediated the IVDD pathological process...

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PMID: 38890795
DOI: 10.1111/jcmm.18492

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