Article

C/EBPβ Drives Anaplastic Thyroid Cancer Dedifferentiation and Radioiodine Resistance via IL-6/JAK/STAT and EMT Activation

2026-05-18

Abstract excerpt

<title>Abstract</title> <p> Anaplastic thyroid carcinoma (ATC) is among the most lethal human malignancies, with a median survival of four months. While ATC is thought to arise from papillary thyroid carcinoma (PTC) through dedifferentiation, the molecular drivers underlying this transition remain poorly defined. Here, we integrated single-cell transcriptomics (43,866 cells; PTC, <italic>n</italic> = 5; ATC,...

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Literature Corpus work: faed9b61-9498-5dac-858d-d4379daa9e19
DOI: 10.21203/rs.3.rs-9248842/v1

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