Article

Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort

2021-02-03

Abstract excerpt

Cerebral small vessel disease (SVD) is a leading cause of vascular cognitive impairment, however the precise nature of SVD-related cognitive deficits, and their associations with structural brain changes, remain unclear. We combined computational volumes and visually-rated MRI markers of SVD to quantify total SVD burden, using data from the Lothian Birth Cohort 1936 (n=540; age:72.6±0.7 years). We found negative a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fac2a0fb-1938-5afe-8228-cb4a72346f5e
DOI: 10.1101/2021.02.02.21250986

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohortDOI 10.1101/2021.02.02.21250986Read

Cerebral Small Vessel Disease Burden and Longitudinal Cognitive Decline from age 73 to 82: the Lothian Birth Cohort 1936Semantic proximity Read

Association of cerebral small vessel disease burden with brain structure and cognitive and vascular risk trajectories in mid-to-late lifeSemantic proximity Read

Mapping the association of cerebral small vessel disease, gray matter integrity and cognitive functionSemantic proximity Read

Clinical Phenotypes Associated With Cerebral Small Vessel Disease: A Study of 45,013 UK Biobank Participants.Semantic proximity Read

White Matter Hyperintensities and the Progression of Frailty—The Tasmanian Study of Cognition and GaitSemantic proximity Read

Cerebral small vessel disease genomics and its implications across the lifespanSemantic proximity Read

Mechanisms of cognitive impairment in cerebral small vessel disease: multimodal MRI results from the St George's cognition and neuroimaging in stroke (SCANS) study.Semantic proximity Read

Cerebral Small Vessel Disease Phenotype and 5-year Mortality in Asymptomatic Middle-to-old Aged IndividualsSemantic proximity Read

Cognitive implications and associated transcriptomic signatures of distinct regional iron depositions in cerebral small vessel diseaseSemantic proximity Read

Cerebral small vessel disease phenotype and 5-year mortality in asymptomatic middle-to-old aged individuals.Semantic proximity Read

A Structural Heart-Brain Axis Mediates the Association Between Cardiovascular Risk and Cognitive FunctionSemantic proximity Read

Cognition in (pre)symptomatic Dutch-type hereditary and sporadic cerebral amyloid angiopathy.Semantic proximity Read