Article

In a Prostate Tumor, Each Cancer Clone Has Unique Transcriptomic Topology of the Immune Response

2025-04-01

Abstract excerpt

Prostate tumor heterogeneity questions the value of the widely used biomarker paradigm for cancer diagnostic and therapy. We hypothesize that each histopathologically distinct tissue region has an unrepeatable dynamic transcriptome organization. The hypothesis was validated by quantifying the transcriptomic topologies and interplay of the toll-like receptors and chemokine signaling pathways in point biopsies of th...

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Literature Corpus work: fa7fb3b2-05e1-581c-8348-edc176afd4e3
DOI: 10.20944/preprints202504.0086.v1

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