Article

Licensing of primordial germ cells for gametogenesis depends on genital ridge signaling

2015-03-01

Abstract excerpt

In mouse embryos at mid-gestation, primordial germ cells (PGCs) undergo licensing to become gametogenesis-competent cells (GCCs), gaining the capacity for meiotic initiation and sexual differentiation. GCCs then initiate either oogenesis or spermatogenesis in response to gonadal cues. Germ cell licensing has been considered to be a cell-autonomous and gonad-independent event, based on observations that some PGCs,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa7980d6-7e23-5023-bd12-e97de678fd0f
DOI: 10.1371/journal.pgen.1005019

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Licensing of primordial germ cells for gametogenesis depends on genital ridge signalingDOI 10.1371/journal.pgen.1005019Read

Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration.Semantic proximity Read

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonadSemantic proximity Read

The journey of a generation: advances and promises in the study of primordial germ cell migrationSemantic proximity Read

Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cellsSemantic proximity Read

Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoterSemantic proximity Read

Endogenous Nodal signaling regulates germ cell potency during mammalian testis developmentSemantic proximity Read

A pilgrim's progress: Seeking meaning in primordial germ cell migrationSemantic proximity Read

A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd.Semantic proximity Read

The role of cadherins during primordial germ cell migration and early gonad formation in the mouseSemantic proximity Read

Mammalian germ cell migration during development, growth, and homeostasisSemantic proximity Read

The transcription factor GATA4 is required for follicular development and normal ovarian function.Semantic proximity Read

BMP and STRA8 act collaboratively to ensure correct mitotic-to-meiotic transition in the fetal mouse ovarySemantic proximity Read