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Article

A P-glycoprotein protects Caenorhabditis elegans against natural toxins.

The EMBO journal - 1 May 1995

Broeks A, Janssen H W, Calafat J, Plasterk R H

Abstract excerpt

P-glycoproteins can cause resistance of mammalian tumor cells to chemotherapeutic drugs. They belong to an evolutionarily well-conserved family of ATP binding membrane transporters. Four P-glycoprotein gene homologs have been found in the nematode Caenorhabditis elegans; this report describes the functional analysis of two. We found that PGP-3 is expressed in both the apical membrane of the excretory cell and in...

Topics

ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Animals, Genetically Modified
Base Sequence
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Chloroquine
Colchicine
DNA, Helminth

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance

Genes, Helminth

Helminth Proteins

Microscopy, Electron

Molecular Sequence Data

Mutation

Tissue Distribution

Toxins, Biological

Source

Open in PubMed Open full text

Identifiers

PMID: 7743993
DOI: 10.1002/j.1460-2075.1995.tb07178.x
PMCID: PMC398285

Genes

PGP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7743993-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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