Article

Early Intervention in preterm infants modulates LINE-1 promoter methylation and neurodevelopment

2019-11-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Early life adversity exposure impacts preterm infants’ neurodevelopment and early intervention protocols may modulate neurodevelopmental outcomes. Neuronal genomes are plastic in response to environment and mobile genetic elements, including LINE-1 (L1), are source of brain genomic mosaicism. Maternal care during early life regulates L1 methylation and copy number variations (...

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Literature Corpus work: fa1f6b4c-0bac-5097-a434-d8ff0a00ffc1
DOI: 10.1101/19011874

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