Article

Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionality

2023-04-04

Abstract excerpt

Cardiovascular disease (CVD) is a multisystemic and multicellular pathology that is generally associated with high levels of atherogenic lipoproteins in circulation. These lipoproteins tend to be retained and modified, for example, aggregated low-density lipoprotein (aggLDL), in the extracellular matrix of different tissues, such as the vascular wall and heart. The uptake of aggLDL generates a significant increase...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f9b13ed8-dd9f-5b31-ab2d-0121224d1983
DOI: 10.21203/rs.3.rs-2688729/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionalityDOI 10.21203/rs.3.rs-2688729/v1Read

HDL Cholesterol-Associated Shifts in the Expression of Preselected Genes Reveal both Pro-Atherogenic and Atheroprotective Effects of HDL in Coronary Artery DiseaseSemantic proximity Read

Targeting lipid metabolism as a new therapeutic strategy for inherited cardiomyopathiesSemantic proximity Read

Lipoproteins, cholesterol homeostasis and cardiac healthSemantic proximity Read

Calcium signalling and ER stress in insulin resistance and atherosclerosisSemantic proximity Read

The physiological roles of apolipoprotein J/clusterin in metabolic and cardiovascular diseasesSemantic proximity Read

Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular DiseaseSemantic proximity Read

iPSC-Derived Endothelial Cells Reveals LDLR-Dysfunction and Dysregulated Gene Expression Profiles in Familial HypercholesterolemiaSemantic proximity Read

Circulating ceramides as biomarkers of cardiovascular disease: Evidence from phenotypic and genomic studiesSemantic proximity Read

Transcriptional regulation profiling reveals PPARA-mediated fatty acid oxidation as a novel therapeutic target in phospholamban R14del cardiomyopathySemantic proximity Read

Low-salt Diet Regulates the Metabolic and Signal Transduc-tion Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological PathwaysSemantic proximity Read

Oxidized LDL-dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy.Semantic proximity Read

Caveolin 1 Reduces High Glucose-Induced Hypertrophy and Inflammatory Fibrosis of H9C2 Cardiomyocytes By Inhibiting NF-κB SignalingSemantic proximity Read