Article

Cis-acting modifiers of trinucleotide repeat instability

2008-01-01

Abstract excerpt

The dynamic expansion of CAG.CTG repeats in otherwise unrelated genes is responsible for a growing number of late-onset progressive disorders, including Huntington disease, myotonic dystrophy type 1 (DM1) and the spinocerebellar ataxias. As toxicity increases with repeat length, the intergenerational expansion of unstable CAG.CTG repeats leads to anticipation, an earlier age-at-onset in successive generations in t...

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Literature Corpus work: f971690e-e3ec-5fd6-b011-4e4184845ce9
DOI: 10.5525/gla.thesis.82368

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