Article

A native chemical chaperone in the human eye lens

2020-12-16

Abstract excerpt

Cataract is one of the most prevalent protein aggregation disorders and still the most common cause of vision loss worldwide. The metabolically quiescent core region of the human lens lacks cellular or protein turnover; it has therefore evolved remarkable mechanisms to resist light-scattering protein aggregation for a lifetime. We now report that one such mechanism involves an unusually abundant lens metabolite,...

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Identifiers and source

Literature Corpus work: f95b48ef-6dcd-5342-8d3c-7f87d9cdcea4
DOI: 10.1101/2020.12.16.423154

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