Article

Benzo[a]pyrene-induced AHR activation in human ESCs primes premature neurogenesis in brain organoids

2026-05-05

Abstract excerpt

Benzo[a]pyrene (BaP), a representative polycyclic aromatic hydrocarbon (PAH), is a widespread environmental toxicant and potent ligand of the aryl hydrocarbon receptor (AHR). Yet, how early developmental exposure to BaP influences human neurodevelopment remains poorly understood. We first examined AHR expression dynamics during human embryonic stem cell (ESC)-derived cerebral organoid development and found that AH...

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Literature Corpus work: ea5b91b9-90e6-58ca-bbb8-08959bfcf3b1
DOI: 10.64898/2026.04.30.722088

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