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Development of a targeted BioPROTAC degrader selective for misfolded SOD1

2025-03-10

Abstract excerpt

<title>Abstract</title> <p>The accumulation of misfolded protein species underlies a broad range of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Due to their dynamic nature, these misfolded proteins have proven challenging to target therapeutically. Here, we specifically target misfolded disease variants of the ALS-associated protein; SOD1, using a biological proteolysis targeting ch...

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Literature Corpus work: 472c65e7-fd82-5abc-b45b-1da2bdff2588
DOI: 10.21203/rs.3.rs-6070925/v1

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