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Article

Oxidized/misfolded superoxide dismutase-1: the cause of all amyotrophic lateral sclerosis?

Annals of neurology - 1 Dec 2007

Kabashi Edor, Valdmanis Paul N, Dion Patrick, Rouleau Guy A

Abstract excerpt

The identification in 1993 of superoxide dismutase-1 (SOD1) mutations as the cause of 10 to 20% of familial amyotrophic lateral sclerosis cases, which represents 1 to 2% of all amyotrophic lateral sclerosis (ALS) cases, prompted a substantial amount of research into the mechanisms of SOD1-mediated toxicity. Recent experiments have demonstrated that oxidation of wild-type SOD1 leads to its misfolding, causing it...

Topics

Amyotrophic Lateral Sclerosis
Animals
Humans
Mutation
Oxidation-Reduction
Protein Folding
Superoxide Dismutase
Superoxide Dismutase-1

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18074357
DOI: 10.1002/ana.21319

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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