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An Immune Epigenetic Insight to COVID-19 Infection

1 Mar 2021

Abstract excerpt

methylation across three CpG sites (cg04013915, cg08559914, cg03536816) determines the host cell's entry. It regulates ACE2 expression by controlling the SIRT1 and KDM5B activity. Further, it regulates Type I and III IFN response by modulating H3K27me3 and H3K4me3 histone mark. SARS-CoV-2 protein with bromodomain and protein E mimics bromodomain histones and evades from host immune response. The 2'-O MTases...

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PMID: 33685230
DOI: 10.2217/epi-2020-0349

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