Article
Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism.
Neurobiology of disease - 1 Oct 2017
Gleave Jacqueline A, Arathoon Lindsay R, Trinh Dennison, Lizal Kristin E, Giguère Nicolas, Barber James H M, Najarali Zainab, Khan M Hassan, Thiele Sherri L, Semmen Mahin S, Koprich James B, Brotchie Jonathan M, Eubanks James H, Trudeau Louis-Eric, Nash Joanne E
Abstract excerpt
Parkinson's disease (PD) is a neurodegenerative movement disorder, which affects approximately 1-2% of the population over 60years of age. Current treatments for PD are symptomatic, and the pathology of the disease continues to progresses over time until palliative care is required. Mitochondria are key players in the pathology of PD. Genetic and post mortem studies have shown a large number of mitochondrial...
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