Article
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
PLoS biology - 1 Mar 2017
de Oliveira Rita Machado, Vicente Miranda Hugo, Francelle Laetitia, Pinho Raquel, Szegö Éva M, Martinho Renato, Munari Francesca, Lázaro Diana F, Moniot Sébastien, Guerreiro Patrícia, Fonseca-Ornelas Luis, Marijanovic Zrinka, Antas Pedro, Gerhardt Ellen, Enguita Francisco Javier, Fauvet Bruno, Penque Deborah, Pais Teresa Faria, Tong Qiang, Becker Stefan, Kügler Sebastian, Lashuel Hilal Ahmed, Steegborn Clemens, Zweckstetter Markus, Outeiro Tiago Fleming
Abstract excerpt
Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease (PD). However, the precise molecular mechanisms involved remain unclear. Here, we provide mechanistic insight into the interplay between sirtuin 2 and...
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