Article

Interplay between intrinsic reprogramming potential and microenvironment controls neuroblastoma cell plasticity and identity

2021-01-08

Abstract excerpt

Two cell identities, noradrenergic and mesenchymal, have been characterized in neuroblastoma cell lines according to their epigenetic landscapes relying on specific circuitries of transcription factors. Yet, their relationship and relative contribution in patient tumors remain poorly defined. Here, we demonstrate that the knock-out of GATA3 , but not of PHOX2A or PHOX2B , in noradrenergic cells induces a mesenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f8a99238-0500-57d6-8d71-ddc1f60a8274
DOI: 10.1101/2021.01.07.425710

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interplay between intrinsic reprogramming potential and microenvironment controls neuroblastoma cell plasticity and identityDOI 10.1101/2021.01.07.425710Read

Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastomaSemantic proximity Read

Plasticity in Neuroblastoma Cell Identity Defines a Noradrenergic-to-Mesenchymal Transition (NMT)Semantic proximity Read

Cholinergic switch associated with morphological differentiation in neuroblastoma.Semantic proximity Read

Malignant Schwann cell precursors mediate intratumoral plasticity in human neuroblastomaSemantic proximity Read

Recent advances in the developmental origin of neuroblastoma: an overviewSemantic proximity Read

Neuroblastoma plasticity during metastatic progression stems from the dynamics of an early sympathetic transcriptomic trajectorySemantic proximity Read

Comparative Single-Cell Transcriptomics of Human Neuroblastoma and Preclinical Models Reveals Conservation of an Adrenergic Cell StateSemantic proximity Read

Mutually exclusive teams-like patterns of gene regulation characterize phenotypic heterogeneity along the noradrenergic-mesenchymal axis in neuroblastoma.Semantic proximity Read

Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes.Semantic proximity Read

Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectorySemantic proximity Read

Single-cell RNA-sequencing of peripheral neuroblastic tumors reveals an aggressive transitional cell state at the junction of an adrenergic-mesenchymal transdifferentiation trajectorySemantic proximity Read

Single-nuclei transcriptomes from human adrenal gland reveals distinct cellular identities of low and high-risk neuroblastoma tumorsSemantic proximity Read