Hypoxia and HIF-1α promote lytic de novo KSHV infection

Abstract excerpt

ABSTRACT The impact of different stress conditions on the oncogenic Kaposi’s sarcoma-associated herpesvirus (KSHV) primary infection that can occur in vivo remains largely unknown. We hypothesized that KSHV can establish a latency or lytic cycle following de novo infection, depending on the conditions of the cellular environment. Previous studies showed that hypoxia is a natural stress condition that promotes...

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