Article

Improving confidence of differential transcription calls in enhancers

2025-09-16

Abstract excerpt

<h4>Motivation</h4> Most disease-associated genetic variants reside within transcribed regulatory elements (tREs). Patterns of differential transcription at tREs can be leveraged to identify upstream regulators and link enhancers to their target genes. But the low transcription levels and high variability in tREs makes identifying high confidence differentially transcribed elements challenging. <h4>Results</h4>...

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Literature Corpus work: f869bf64-3363-50e2-99ef-d877f186b502
DOI: 10.1101/2025.09.12.675852

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