Article

Phosphorylation of dynamin-related protein 1 at Ser616 promotes autophagy to suppress Mycobacterium tuberculosis survival via the ROS/HIF-1α axis in macrophages

2026-08-10

Abstract excerpt

<title>Abstract</title> <p>Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of global mortality from a single infectious agent. The mitochondrial fission protein dynamin-related protein 1 (Drp1) is known to modulate host immunity, but its role in anti-mycobacterial defense is unclear. Here, we found that Mtb infection triggers Drp1 phosphorylation at Ser616 in macrophages and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f84caf98-86fb-5f4e-81c0-f0761b2a7021
DOI: 10.21203/rs.3.rs-10550606/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of dynamin-related protein 1 at Ser616 promotes autophagy to suppress Mycobacterium tuberculosis survival via the ROS/HIF-1α axis in macrophagesDOI 10.21203/rs.3.rs-10550606/v1Read

Autophagy: A new strategy for host-directed therapy of tuberculosisSemantic proximity Read

Mitochondria: Powering the Innate Immune Response to Mycobacterium tuberculosis Infection.Semantic proximity Read

mTOR-regulated Mitochondrial Metabolism Limits Mycobacterium-induced CytotoxicitySemantic proximity Read

mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicitySemantic proximity Read

ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNASemantic proximity Read

The ubiquitin ligase TRIM32 promotes the autophagic response to Mycobacterium tuberculosis infection in macrophagesSemantic proximity Read

Fatty acid oxidation impairs macrophage effector functions that control <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infectionSemantic proximity Read

Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis SusceptibilitySemantic proximity Read

Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophagesSemantic proximity Read

LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis.Semantic proximity Read