Article

Structural basis of ethnic-specific variants of PAX4 associated with type 2 diabetes

2020-03-26

Abstract excerpt

Recently, we conducted genome-wide association studies of type 2 diabetes (T2D) in a Japanese population, which identified 20 novel T2D loci that were not associated with T2D in Europeans. Moreover, nine novel missense risk variants, such as those of PAX4 , were not rare in the Japanese population, but rare in Europeans. We report in silico structural analysis of ethnic-specific variants of PAX4 , which suggest...

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Literature Corpus work: f8223569-c361-5105-b59e-14c7c320125c
DOI: 10.1101/2020.03.24.006254

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