Article

Chemical augmentation of the validated HepaRG <sup>TM</sup> CYP induction test method Part 2: Additional laboratory study supported by mRNA analysis

2026-06-20

Abstract excerpt

Cytochrome P450 (CYP)-mediated biotransformation of endogenous and xenobiotic substances can lead to altered exposure, toxicological impact, or adverse drug reactions. CYP induction data are fundamental to regulatory chemical toxicity hazard assessment because they directly affect the in vivo fate of xenobiotics, potentially influencing their safety and efficacy of pharmaceuticals, and impacting the safety assess...

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Literature Corpus work: f810fdee-bf40-5d57-b274-e7f62d2da625
DOI: 10.64898/2026.06.16.732650

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