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Complement Biosensors Identify a Classical Pathway Stimulus in Complement-Mediated Hemolytic Uremic Syndrome

2024-06-02

Abstract excerpt

Complement-mediated hemolytic uremic syndrome (CM-HUS) is a thrombotic microangiopathy characterized by germline variants or acquired antibodies to complement proteins and regulators. Building upon our prior experience with the modified Ham (mHam) assay for ex vivo diagnosis of complementopathies, we have developed an array of cell-based complement “biosensors’’ by selective removal of complement regulatory protei...

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Literature Corpus work
f7c15861-f031-532f-b42e-ab8dd77b3728
DOI
10.1101/2024.05.29.596475
Open publication

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