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Complement and Bacterial Infections: From Molecular Mechanisms to Therapeutic Applications

1 Jan 2018

Abstract excerpt

Complement is a complex protein network of plasma, and an integral part of the innate immune system. Complement activation results in the rapid clearance of bacteria by immune cells, and direct bacterial killing via large pore-forming complexes. Here we review important recent discoveries in the complement field, focusing on interactions relevant for the defense against bacteria. Understanding the molecular...

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PMID: 30149378
DOI: 10.1159/000491439

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