Diamond Blackfan anemia 2008-2009: broadening the scope of ribosome biogenesis disorders.

Abstract excerpt

PURPOSE OF REVIEW: Diamond Blackfan anemia (DBA) is an inherited bone marrow failure syndrome characterized by erythroid failure, congenital anomalies and predisposition to cancer. Recently, the notion of DBA as a disorder of ribosome biogenesis has been clarified. Correlations between molecular underpinnings and disease pathophysiology, while elusive, are beginning to emerge. Advances in these areas will be...

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