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Article

Age-dependent degeneration of an identified adult leg motor neuron in a Drosophila SOD1 model of ALS.

Biology open - 21 Oct 2020

Agudelo Anthony, St Amand Victoria, Grissom Lindsey, Lafond Danielle, Achilli Toni, Sahin Asli, Reenan Robert, Stilwell Geoff

Abstract excerpt

Mutations in superoxide dismutase 1 (SOD1) cause familial amyotrophic lateral sclerosis (ALS) in humans. ALS is a neurodegenerative disease characterized by progressive motor neuron loss leading to paralysis and inevitable death in affected individuals. Using a gene replacement strategy to introduce disease mutations into the orthologous Drosophila sod1 (dsod1) gene, here, we characterize changes at the...

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Identifiers

PMID: 32994185
DOI: 10.1242/bio.049692
PMCID: PMC7595701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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