Article

Production and secretion of functional full-length SARS-CoV-2 spike protein in <i>Chlamydomonas reinhardtii</i>

2021-12-14

Abstract excerpt

The spike protein is the major protein on the surface of coronaviruses. It is therefore the prominent target of neutralizing antibodies and consequently the antigen of all currently admitted vaccines against SARS-CoV-2. Since it is a 1273-amino acids glycoprotein with 22 N-linked glycans, the production of functional, full-length spike protein was limited to mammalian and insect cells, requiring complex culture me...

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Literature Corpus work: f740158d-19d4-51b1-9331-34da8c1f815d
DOI: 10.1101/2021.12.13.472433

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