Article
A variant of the KLK4 gene is expressed as a cis sense-antisense chimeric transcript in prostate cancer cells.
RNA (New York, N.Y.) - 1 Jun 2010
Lai John, Lehman Melanie L, Dinger Marcel E, Hendy Stephen C, Mercer Tim R, Seim Inge, Lawrence Mitchell G, Mattick John S, Clements Judith A, Nelson Colleen C
Abstract excerpt
In humans, more than 30,000 chimeric transcripts originating from 23,686 genes have been identified. The mechanisms and association of chimeric transcripts arising from chromosomal rearrangements with cancer are well established, but much remains unknown regarding the biogenesis and importance of other chimeric transcripts that arise from nongenomic alterations. Recently, a SLC45A3-ELK4 chimera has been shown to...
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