Article
Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry.
The pharmacogenomics journal - 1 Apr 2021
Wenric Stephane, Jeff Janina M, Joseph Thomas, Yee Muh-Ching, Belbin Gillian M, Owusu Obeng Aniwaa, Ellis Stephen B, Bottinger Erwin P, Gottesman Omri, Levin Matthew A, Kenny Eimear E
Abstract excerpt
The emergence of genomic data in biobanks and health systems offers new ways to derive medically important phenotypes, including acute phenotypes occurring during inpatient clinical care. Here we study the genetic underpinnings of the rapid response to phenylephrine, an α1-adrenergic receptor agonist commonly used to treat hypotension during anesthesia and surgery. We quantified this response by extracting blood...
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