Article

The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer

2020-01-11

Abstract excerpt

Chromatin remodeling SWItch/Sucrose-NonFermentable (SWI/SNF) complexes, initially identified in yeast 20 years ago, are evolutionarily conserved multi-subunit protein complexes that use the energy from hydrolysis of adenosine triphosphate (ATP) to remodel nucleosome structure and modulate transcription. Mutations in proteins of SWI/SNF complexes occur in 20% of human cancers including ovarian cancer (OC). Approxim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6a9cdd2-330f-5a93-b991-c35b1466bb59
DOI: 10.1101/2020.01.10.902528

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancerDOI 10.1101/2020.01.10.902528Read

The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer.Semantic proximity Read

Aberrant SWI/SNF Complex Members Are Predominant in Rare Ovarian Malignancies—Therapeutic Vulnerabilities in Treatment-Resistant SubtypesSemantic proximity Read

Chromatin remodeling (SWI/SNF) complexes, cancer, and response to immunotherapySemantic proximity Read

SWI/SNF complex gene variations are associated with a higher tumor mutational burden and a better response to immune checkpoint inhibitor treatment: a pan-cancer analysis of next-generation sequencing data corresponding to 4591 casesSemantic proximity Read

Mammalian SWI/SNF Complex Genomic Alterations and Immune Checkpoint Blockade in Solid Tumors.Semantic proximity Read

Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapySemantic proximity Read

Potential therapeutic targets in ARID1A-mutated cancers.Semantic proximity Read

SWI/SNF complexes in hematological malignancies: biological implications and therapeutic opportunities.Semantic proximity Read

Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer.Semantic proximity Read

Inactivating Mutations in SWI/SNF Chromatin Remodeling Genes in Human CancerSemantic proximity Read

ARID1A Hypermethylation Disrupts Transcriptional Homeostasis to Promote Squamous Cell Carcinoma ProgressionSemantic proximity Read