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Article

RABL6A Regulates Schwann Cell Senescence in an RB1-Dependent Manner

20 May 2021

Abstract excerpt

Schwann cells are normally quiescent, myelinating glia cells of the peripheral nervous system. Their aberrant proliferation and transformation underlie the development of benign tumors (neurofibromas) as well as deadly malignant peripheral nerve sheath tumors (MPNSTs). We discovered a new driver of MPNSTs, an oncogenic GTPase named RABL6A, that functions in part by inhibiting the RB1 tumor suppressor. RB1 is a...

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PMID: 34065204
DOI: 10.3390/ijms22105367

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