Article

The time of strong actomyosin binding depends on electrostatic interactions within the force generating region in human cardiac myosin

2020-04-22

Abstract excerpt

Two single mutations, R694N and E45Q, were introduced in the beta isoform of human cardiac myosin to remove permanent salt bridges E45:R694 and E98:R694 in the force-generating region of myosin head. Beta isoform-specific bridges E45:R694 and E98:R694 were discovered in the molecular dynamics simulations of the alpha and beta myosin isoforms. Alpha and beta isoforms exhibit different kinetics, ADP dissociates slow...

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Literature Corpus work: f6907959-8ba9-52b5-a7d4-832f98cdfc11
DOI: 10.1101/2020.04.21.054403

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