Article

Vitamin D, chronic pain, and depression: linear and non-linear Mendelian randomization analyses

2023-04-17

Abstract excerpt

<h4>ABSTRACT</h4> Vitamin D deficiency has been linked to various chronic pain conditions. However, randomized trials of vitamin D supplementation have had mixed results. In contrast, systematic reviews of randomized trials indicate a protective effect of vitamin D supplementation on depression. We undertake a Mendelian randomization investigation in UK Biobank, a study of UK residents aged 40-65 at recruitment. W...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f624cae7-c29b-57f7-9711-a865b4835a22
DOI: 10.1101/2023.04.12.23288467

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vitamin D, chronic pain, and depression: linear and non-linear Mendelian randomization analysesDOI 10.1101/2023.04.12.23288467Read

Vitamin D, chronic pain, and depression: linear and non-linear Mendelian randomization analyses.Semantic proximity Read

Relationship between Serum 25(OH)D and Depression: Causal Evidence from a Bi-Directional Mendelian Randomization Study.Semantic proximity Read

Phenome-wide Mendelian-randomization study of genetically determined vitamin D on multiple health outcomes using the UK Biobank studySemantic proximity Read

Phenome-wide screening of the putative causal determinants of depression using genetic data.Semantic proximity Read

Vitamin D and the Risk of Depression: A Causal Relationship? Findings from a Mendelian Randomization StudySemantic proximity Read

Serum 25-Hydroxyvitamin D Concentrations and Major Depression: A Mendelian Randomization StudySemantic proximity Read

Genetic Causal Association Between Vitamin E and Depression: A Two-Sample Mendelian Randomization Study.Semantic proximity Read

Causal effect of serum 25-hydroxyvitamin D levels on low back pain: A two-sample mendelian randomization studySemantic proximity Read

Depression and Osteoporosis: A Mendelian Randomization Study.Semantic proximity Read

A comprehensive genetic and epidemiological association analysis of vitamin D with common diseases/traits in the UK Biobank.Semantic proximity Read

Mendelian randomization highlights sleep disturbances mediated the effect of depression on chronic pain.Semantic proximity Read

The causal role of circulating vitamin D concentrations in human complex traits and diseases: a large-scale Mendelian randomization studySemantic proximity Read