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Article

Vitamin D, chronic pain, and depression: linear and non-linear Mendelian randomization analyses.

Translational psychiatry - 4 Jul 2024

Bassett Emily, Gjekmarkaj Eva, Mason Amy M, Zhao Sizheng Steven, Burgess Stephen

Abstract excerpt

Vitamin D deficiency has been linked to various chronic pain conditions. However, randomized trials of vitamin D supplementation have had mixed results. In contrast, systematic reviews of randomized trials indicate a protective effect of vitamin D supplementation on depression. We undertake a Mendelian randomization investigation in UK Biobank, a study of UK residents aged 40-65 at recruitment. We perform linear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38965219
DOI: 10.1038/s41398-024-02997-7
PMCID: PMC11224391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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