Article

Physiological and pharmacological factors affecting sickle cell function

2020-01-01

Abstract excerpt

Sickle cell disease (SCD) is one of the most common autosomal-recessive genetic disorders affecting millions worldwide. The three most significant abnormal features of RBCs from SCA patients are haemoglobin (HbS) polymerisation, phosphatidylserine (PS) exposure and significantly increased cation permeability via the KCl cotransporter (KCC), and are critical to the pathogenesis of SCD. The outcome of these abnormal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c7a9bd5-1cc5-50c1-87fc-44a09996c157
DOI: 10.17863/cam.62778

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Physiological and pharmacological factors affecting sickle cell functionDOI 10.17863/cam.62778Read

Novel approach towards pathogenesis and treatment of sickle cell diseaseSemantic proximity Read

Pathophysiological-Based Approaches to Treatment of Sickle Cell DiseaseSemantic proximity Read

Blood rheology and vascular function in sickle cell trait and sickle cell disease: From pathophysiological mechanisms to clinical usefulnessSemantic proximity Read

Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular levelSemantic proximity Read

Pathophysiology and therapy for haemoglobinopathies. Part I: sickle cell disease.Semantic proximity Read

Pathophysiology of sickle cell disease: role of cellular and genetic modifiers.Semantic proximity Read

Disorders of erythrocyte hydrationSemantic proximity Read

Sickle cell anaemia: progress in pathogenesis and treatment.Semantic proximity Read

The role of blood rheology in sickle cell disease.Semantic proximity Read

Knowledge insufficient: the management of haemoglobin SC disease.Semantic proximity Read

Pathophysiology of sickle cell disease.Semantic proximity Read

Cation transport and volume regulation in sickle red blood cellsSemantic proximity Read