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Automated Fast-Flow Synthesis of Antisense Phosphorodiamidate Morpholino Oligomers

2020-07-22

Abstract excerpt

The antisense phosphorodiamidate morpholino oligomer (PMO) drugs Eteplirsen and Golodirsen are improving the lives of some Duchenne muscular dystrophy (DMD) patients, but treating all DMD subtypes would require the development of over 50 novel antisense therapies. To rapidly prototype personalized PMO for diseases such as DMD, we designed a fully automated flow-based oligonucleotide synthesizer. Our optimize...

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Literature Corpus work
b20fabb4-af0f-5526-815d-4c3ba0852a9e
DOI
10.26434/chemrxiv.12685886.v1
Open publication

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Automated Fast-Flow Synthesis of Antisense Phosphorodiamidate Morpholino OligomersDOI 10.26434/chemrxiv.12685886.v1
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