Article

Longitudinal transcriptomic and epigenetic analysis in astronauts reveals dynamic immune response to spaceflight

2023-11-09

Abstract excerpt

With the advance of the space industry, the number of astronauts is increasing exponentially. A better understanding of the molecular changes in astronauts in response to spaceflight is required. Here we studied the transcriptomic and epigenetic changes that are subjected to spaceflight. We analyzed the blood samples of two astronauts collected at three timepoints of two weeks before (T0), twenty-four hours after...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 14ce596c-599e-5212-8076-6af65dbdefdc
DOI: 10.21203/rs.3.rs-3493131/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Longitudinal transcriptomic and epigenetic analysis in astronauts reveals dynamic immune response to spaceflightDOI 10.21203/rs.3.rs-3493131/v1Read

Designing a novel monitoring approach for the effects of space travel on astronauts’ healthSemantic proximity Read

Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflightSemantic proximity Read

Microgravity Remodels Longevity Networks in Astronaut PBMCs: Integrated Findings of Telomere Elongation, DNA Repair Responses, and miRNA SuppressionSemantic proximity Read

Spaceflight modulates gene expression in the whole blood of astronautsSemantic proximity Read

Spatially resolved multiomics on the neuronal effects induced by spaceflightSemantic proximity Read

Aging and putative frailty biomarkers are altered by spaceflightSemantic proximity Read

Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflightSemantic proximity Read

Aging and putative frailty biomarkers are altered by spaceflightSemantic proximity Read

Systemic Genome Correlation Loss as a Central Characteristic of SpaceflightSemantic proximity Read

Microgravity-Induced Immune Plasticity and Temporal Modulation of Gene Networks and T Cell Subsets During the MESSAGE Science Mission in Axiom-3 on the ISSSemantic proximity Read

Assessing Immune Stability in Space: Haematological and T Cell Profiling of Astronauts During the MESSAGE Science Mission in Axiom-3 on the ISSSemantic proximity Read

Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retinaSemantic proximity Read